TABLE 2.
Significant obesity-DNA methylation associations overall and by CRT status
| Loci characteristics | All subjects | Chemotherapy only | CRT+Chemotherapy | Obesity-CRT interaction | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CpG Site | Chr | Gene | Δβ | P-value | FDR | Δβ | P-value | FDR | Δβ | P-value | FDR | P-value |
| cg00431050 | 10 | ELOVL3 | 0.0169 | 9.37E-03 | 0.103 | 0.0308 | 4.29E-06 | 0.001 | 0.0017 | 8.61E-01 | 0.943 | 0.040 |
| cg03523676 | 14 | CPNE6 | 0.0257 | 1.20E-02 | 0.103 | 0.0502 | 1.09E-05 | 0.002 | −0.0013 | 9.28E-01 | 0.971 | 0.023 |
| cg06500161 | 21 | ABCG1 | 0.0335 | 6.24E-05 | 0.012 | 0.0450 | 4.25E-05 | 0.003 | 0.0281 | 1.00E-02 | 0.149 | 0.379 |
| cg07728579 | 15 | FSD2 | 0.0101 | 2.19E-02 | 0.133 | 0.0181 | 1.14E-04 | 0.006 | 0.0008 | 9.07E-01 | 0.959 | 0.072 |
| cg08972190 | 7 | MAD1L1 | 0.0059 | 6.68E-02 | 0.236 | 0.0161 | 6.12E-04 | 0.014 | −0.0031 | 4.17E-01 | 0.691 | 0.019 |
| cg01101459 | 1 | NA | 0.0181 | 7.80E-02 | 0.261 | 0.0456 | 6.60E-04 | 0.014 | −0.0047 | 7.37E-01 | 0.875 | 0.034 |
| cg27184903 | 15 | APBA2 | 0.0176 | 1.24E-02 | 0.103 | 0.0275 | 5.62E-04 | 0.014 | 0.0082 | 4.28E-01 | 0.698 | 0.230 |
| cg14017402 | 2 | NA | 0.0167 | 2.06E-02 | 0.133 | 0.0296 | 5.09E-04 | 0.014 | 0.0087 | 3.87E-01 | 0.684 | 0.315 |
| cg13708645 | 12 | KDM2B | 0.0347 | 6.47E-03 | 0.103 | 0.0484 | 5.28E-04 | 0.014 | 0.0235 | 2.07E-01 | 0.47 | 0.383 |
| cg10927968 | 11 | NA | 0.0082 | 2.76E-01 | 0.494 | 0.0318 | 1.11E-03 | 0.017 | −0.0122 | 2.48E-01 | 0.537 | 0.024 |
| cg27243685 | 21 | ABCG1 | 0.0138 | 4.09E-02 | 0.193 | 0.0256 | 1.17E-03 | 0.017 | 0.0023 | 8.15E-01 | 0.915 | 0.117 |
| cg02711608 | 19 | SLC1A5 | −0.0182 | 9.49E-03 | 0.103 | −0.0287 | 8.98E-04 | 0.017 | −0.0143 | 1.37E-01 | 0.442 | 0.571 |
| cg04577162 | 7 | RFC2 | 0.0266 | 1.47E-03 | 0.057 | 0.0368 | 9.86E-04 | 0.017 | 0.0222 | 5.73E-02 | 0.33 | 0.705 |
| cg13922488 | 19 | PKN1 | 0.0141 | 5.27E-02 | 0.222 | 0.0300 | 1.91E-03 | 0.024 | −0.0006 | 9.46E-01 | 0.979 | 0.062 |
| cg27547344 | 1 | TIE1 | 0.0200 | 1.54E-03 | 0.057 | 0.0267 | 1.95E-03 | 0.024 | 0.0115 | 1.57E-01 | 0.442 | 0.435 |
| cg11024682 | 17 | SREBF1 | 0.0222 | 1.43E-01 | 0.354 | 0.0533 | 2.39E-03 | 0.026 | 0.0005 | 9.80E-01 | 0.986 | 0.138 |
| cg01243823 | 16 | NOD2 | −0.0337 | 6.59E-04 | 0.057 | −0.0333 | 2.35E-03 | 0.026 | −0.0361 | 1.05E-02 | 0.149 | 0.867 |
| cg18307303 | 5 | IL12B | 0.0150 | 1.58E-02 | 0.112 | 0.0237 | 2.63E-03 | 0.027 | 0.0075 | 3.81E-01 | 0.681 | 0.315 |
| cg26403843 | 5 | RNF145 | 0.0458 | 2.62E-03 | 0.069 | 0.0530 | 2.84E-03 | 0.028 | 0.0491 | 2.87E-02 | 0.22 | 0.812 |
| cg11832534 | 1 | WDR8 | 0.0105 | 1.24E-01 | 0.344 | 0.0243 | 3.56E-03 | 0.029 | 0.0014 | 8.83E-01 | 0.947 | 0.169 |
| cg07037944 | 15 | DAPK2 | −0.0162 | 1.15E-02 | 0.103 | −0.0260 | 3.12E-03 | 0.029 | −0.0113 | 1.56E-01 | 0.442 | 0.303 |
| cg10438589 | 4 | NA | 0.0168 | 1.69E-01 | 0.366 | 0.0430 | 3.53E-03 | 0.029 | −0.0024 | 8.85E-01 | 0.947 | 0.353 |
| cg05720226 | 7 | ST7 | 0.0086 | 1.46E-01 | 0.354 | 0.0192 | 3.25E-03 | 0.029 | 0.0053 | 5.06E-01 | 0.752 | 0.467 |
| cg25217710 | 1 | NA | 0.0136 | 2.06E-01 | 0.426 | 0.0354 | 3.98E-03 | 0.03 | −0.0057 | 7.20E-01 | 0.866 | 0.120 |
| cg26952928 | 8 | SLC45A4 | 0.0110 | 9.51E-02 | 0.292 | 0.0207 | 3.97E-03 | 0.03 | 0.0045 | 6.38E-01 | 0.811 | 0.229 |
| cg23232188 | 3 | EAF2 | 0.0143 | 3.61E-01 | 0.573 | 0.0530 | 5.08E-03 | 0.033 | −0.0131 | 5.42E-01 | 0.762 | 0.070 |
| cg08443038 | 16 | CBFA2T3 | −0.0031 | 4.52E-01 | 0.655 | −0.0130 | 5.10E-03 | 0.033 | 0.0051 | 3.90E-01 | 0.684 | 0.071 |
| cg07682160 | 19 | UPF1 | 0.0189 | 2.14E-02 | 0.133 | 0.0262 | 5.37E-03 | 0.033 | 0.0171 | 1.53E-01 | 0.442 | 0.784 |
| cg10549088 | 3 | NA | 0.0345 | 1.24E-03 | 0.057 | 0.0415 | 4.68E-03 | 0.033 | 0.0347 | 1.01E-02 | 0.149 | 0.968 |
| cg04927537 | 17 | LGALS3BP | 0.0447 | 3.58E-03 | 0.075 | 0.0519 | 5.14E-03 | 0.033 | 0.0451 | 2.76E-02 | 0.22 | 0.998 |
| cg06192883 | 15 | MYO5C | 0.0195 | 2.24E-02 | 0.133 | 0.0331 | 6.02E-03 | 0.035 | 0.0075 | 4.68E-01 | 0.731 | 0.279 |
| cg22012981 | 3 | ACOX2 | 0.0305 | 1.84E-03 | 0.057 | 0.0307 | 5.80E-03 | 0.035 | 0.0306 | 2.99E-02 | 0.22 | 0.812 |
| cg03050965 | 1 | S1PR1 | 0.0025 | 2.81E-01 | 0.495 | 0.0081 | 7.04E-03 | 0.039 | −0.0035 | 2.96E-01 | 0.593 | 0.032 |
| cg19373099 | 2 | NA | 0.0239 | 2.31E-01 | 0.443 | 0.0631 | 7.05E-03 | 0.039 | −0.0192 | 4.89E-01 | 0.738 | 0.072 |
| cg26687842 | 13 | LOC646982 | 0.0111 | 1.67E-01 | 0.366 | 0.0253 | 7.47E-03 | 0.039 | −0.0017 | 8.82E-01 | 0.947 | 0.149 |
| cg22488164 | 12 | PLBD1 | 0.0227 | 8.14E-02 | 0.263 | 0.0414 | 7.29E-03 | 0.039 | 0.0171 | 3.72E-01 | 0.675 | 0.417 |
| cg05648472 | 11 | PRDM11 | 0.0143 | 2.33E-02 | 0.134 | 0.0216 | 8.13E-03 | 0.041 | 0.0065 | 4.08E-01 | 0.689 | 0.310 |
| cg25649826 | 17 | USP22 | 0.0110 | 1.41E-01 | 0.354 | 0.0223 | 8.36E-03 | 0.041 | 0.0058 | 6.18E-01 | 0.81 | 0.594 |
| cg00673344 | 3 | NA | −0.0114 | 6.68E-02 | 0.236 | −0.0196 | 8.96E-03 | 0.043 | −0.0041 | 5.82E-01 | 0.792 | 0.182 |