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. Author manuscript; available in PMC: 2018 Dec 16.
Published in final edited form as: Science. 2017 Apr 14;356(6334):200–205. doi: 10.1126/science.aak9510

Fig. 4. Programmed cell death 1 (PD-1) expression identifies both viral and non-viral tumor antigen-specific T cells in the circulation of patients with metastatic cervical carcinoma before treatment.

Fig. 4.

(A) Expression of PD-1 on CD4+ and CD8+ T cells from PB before treatment for (left) patient 3775 and (right) patient 3853. (B and C) Frequency of individual tumor antigen-specific TCRB clonotypes as identified for (B) patient 3775 in TIL-3775 and for (C) patient 3853 in TIL-3853 (Fig. 2D) within sorted PD-1− and PD-1+ PB CD4+ and CD8+ T-cell subsets was determined by TCRB deep sequencing analysis. Graphs display CD4+ and CD8+ clonotypes. The specificity of each TCRB clonotype and its rank in the infused TIL is indicated next to the symbol. ND in (B) indicates clonotypes not detected (<0.001%) in sorted PD-1− population (symbols shown on the x-axis).