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. Author manuscript; available in PMC: 2018 Dec 16.
Published in final edited form as: Sci Transl Med. 2015 Mar 18;7(279):279ra38. doi: 10.1126/scitranslmed.3010841

Fig. 2. Overexpression of miR302–367 cluster in the developing heart results in increased cardiomyocyte proliferation and cardiomegaly.

Fig. 2.

(A) At E18.5, Nkx2.5cre:R26R-miR302–367Tg/+ mutants have an enlarged heart with thickened ventricular myocardium and ventricular septal defects compared to Nkx2.5cre controls. (B) Cardiomegaly and increased cardiomyocyte proliferation in Nkx2.5cre:R26R-miR302–367Tg/+ mutant hearts at P20. (A and B) Immunostainings for PH3 and a-actinin and wheat germ agglutinin (WGA) show the number of mitotic cardiomyocytes. Scale bars, 100 mm. High-magnification reveals PH3+ cardiomyocytes. LA, left atrium. Data are means ± SEM (n = 3). P values determined by Student’s t test.