Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overall structures of ORC from different species.
(a) Schematic alignment of ORC subunits and CDC6. The RecA (or RecA-like) and Lid domains are part of the AAA+ domain common in this clade of AAA+ ATPases. A winged helix (WH) domain is at the C-terminus in all subunits except for ORC6.
Structures of (b, e) Saccharomyces cerevisiae ORC, (c, f) Drosophila melanogaster ORC and (d, g and h) human ORC shown in perpendicular views.
