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. 2018 Dec 10;9:2870. doi: 10.3389/fimmu.2018.02870

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Copyright © 2018 Omura, Kawai, Sato, Martinez, Minagar, Al-Kofahi, Yun, Cvek, Trutschl, Alexander and Tsunoda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Organ-specific pathology induced by Theiler's murine encephalomyelitis virus (TMEV). TMEV induces pathology in two organs: inflammatory demyelination in the central nervous system (CNS) and inflammation followed with fibrosis in the heart, whose susceptibilities differ among mouse strains (9, 10). Although TMEV can infect the CNS and the heart during the acute phase, persistent viral infection is observed only in the CNS. CNS disease can be induced only by intracerebral inoculation. On the other hand, both peripheral and intracerebral routes of viral inoculation result in myocarditis, while peripheral inoculation induces more severe cardiac disease. (Left) Inflammatory demyelination in the spinal cord of TMEV-induced demyelinating disease (TMEV-IDD). Luxol fast blue stain. CD3 immunohistochemical staining of consecutive sections showed that T cells were present in perivascular cuffing and meningitis (Arrows). Bar: 100 μm (Right) Inflammation and fibrosis in the heart during phase III of TMEV-induced myocarditis. Masson's trichrome stain. CD3 immunohistochemical staining showed T cell infiltration (Arrows) in the heart. Bar: 50 μm.