Fig. 17.

There is a site-dependent effect on pulmonary ventilation (V̇i; A and C) and breathing frequency (B and D)of dialysis of a µ-opioid inhibitory receptor agonist. Unilateral (A and B) and bilateral (C and D) dialysis of the agonist (closed circles) into the HMN decreased P < 0.016) or did not change (P = 462) V̇i and breathing frequency_. These findings contrast to unchanged V̇i and breathing frequency (Fig. 13) or increased values (Fig. 14) during dialysis into the ventral respiratory column (VRC). The black line denotes when DAMGO was dialyzed.