Mean arterial pressure (MAP) and heart rate (HR) in sham-operated (SHAM) and ovariectomized (OVX) salt-sensitive (SS) and salt-resistant (SR) rats at 10 mo of age. After being weaned, all rats were maintained on a low-sodium diet (<0.13% NaCl). Ovariectomies or sham surgeries were conducted at 6 wk old. Shown is the terminal MAP (A) and HR (B) measured at 10 mo. The data in SR-SHAM (n = 7), SR-OVX (n = 6), SS-SHAM (n = 7), and SS-OVX (n = 5) are expressed as means ± SE; *P < 0.05 vs. SHAM, same strain or #P < 0.0001 vs. SR, same gonadal status, by Tukey’s multiple comparison in two-way ANOVA; SS/JrHsd/Env, salt-sensitive rats developed by John Rapp, distributed by Harlan, and purchased from Envigo; SR/JrHsd/Env, salt-resistant rats developed by John Rapp, distributed by Harlan, and purchased from Envigo.