Fig. 6.

Renal pathology in SS and SR rats at 4 and 8 mo of age. After being weaned, all rats were maintained on a low-sodium diet (<0.13% NaCl). Shown are representative images of renal pathology (A) and quantification of glomerular injury (B) in transverse sections of right kidneys from 4-mo-old and 8-mo-old SS and SR rats; ~100 glomeruli were studied per section, and one section was analyzed per rat. Images were taken at ×4 and ×20 magnification of glomeruli and interstitial tubular space. Quantification of renal pathology in 4-mo-old SR (n = 8) and SS (n = 7) rats and 8-mo-old SR (n = 7) and SS (n = 6) animals is expressed as the means ± SE of the percentage of glomerular injury in each kidney; #P < 0.0001 vs. SR, same age; ‡P < 0.006 vs. 4 mo, same strain; two-way ANOVA and Sidak’s post hoc analysis; SS/JrHsd/Env, salt-sensitive rats developed by John Rapp, distributed by Harlan, and purchased from Envigo; SR/JrHsd/Env, salt-resistant rats developed by John Rapp, distributed by Harlan, and purchased from Envigo.