Fig. 2.

Lung proteomics of 1-wk-old mice exposed to hyperoxia. Lung tissues of mice exposed to normoxia or hyperoxia (n = 3/group) for 7 days were analyzed using RPPA. Heatmap of unsupervised hierarchical clustering of hyperoxia-exposed mice inclusive of significantly DEPs (P < 0.05) (A). Significantly downregulated proteins (B) and upregulated proteins (C) by hyperoxia. GO analysis of significantly downregulated (D) and upregulated (E) biological processes by hyperoxia (FDR < 0.05; P < 0.05). FDR, false discovery rate; DEP, differentially expressed protein; GO, gene ontology; RPPA, reverse-phase protein array; see main text for relevant definitions of genes.