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PKCε knockout (KO) mice are spared from cilia beat frequency (CBF) slowing of aging. Tracheal rings were cut from young (2–4 mo) and old (12–18 mo) wild-type (WT) and PKCε KO mice. These mice were on a C57BL/6 background and were raised side by side. There was a significant decrease in CBF in the old WT mice (P = 0.005), compared with the young WT mice. The old KO mice had the same CBF as the young KO mice. Young WT, n = 12; old WT, n = 18; young KO, n = 10; old KO, n = 16.
