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. 2018 Sep 6;315(5):L891–L909. doi: 10.1152/ajplung.00011.2018

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Fig. 1. — Selectivity of the lesions induced by saporin-substance P conjugate (SSP-SAP) injection within the retrotrapezoid nucleus (RTN) region. Representative photomicrographs of rats treated with saline (control; A, C, E, and G) or SSP-SAP (B, D, F, and H). Neurokinin-1 receptor (NK1R)-immunoreactivity (ir) at the RTN (A and B), BötC (C and D), pre-BötC (E and F), and raphe pallidus/parapyramidal (RPa/Ppy) (G and H) levels. Analysis of the extent of NK1R-ir (I) in the regions observed in A–F. NK1R-ir in SSP-SAP group is expressed as a percentage of the immunoreactivity observed in the control group. Scale bar = 0.5 mm. *Different from control group, P < 0.05. 7, facial motor nucleus; Amb, nucleus ambigus; BötC, Bötzinger complex; py, pyramide tract.