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In simulation, the control model is more sensitive to CO2 concentration. Motoneuron output for the phrenic nerve (PN) and the abdominal nerve (AbN) are depicted for simulations with gradually increasing CO2 partial pressure for the control model and the saporin-substance P conjugate (SSP-SAP) lesion model. CO2 partial pressure is incremented in steps of 0.25% from 0% to 10%. Lightly shaded regions emphasize activity at 1%, 3%, 5%, 8%, and 10% CO2.
