Table 1.
The excitatory drives and the corresponding source populations considered in the model
Target Population | Excitatory Drive [Synaptic Weight] or Source Population [weight of synaptic input from single neuron] |
---|---|
IE (pons) | post-I [0.35]; ramp-I [0.2] |
RVLM | Drive VLM [1]; IE [0.05]; early-I (2) [−0.01]; late-E [0.03]a; post-I [−0.05] |
aug-E (BötC) | Drive pons [1.2]b; drive RTN [1.5]b,c; early-I (1) [−0.135]; late-E [0.03]; post-I [−0.3] |
early-I (1) (pre-BötC) | Drive pons [0.6]b; drive RTN [1.5]b,c; drive raphe [0.5]; aug-E [−0.265]; post-I [−0.45]; pre-I/I [0.05] |
early-I (2) (rVRG) | Drive pons [2.5]; aug-E [−0.25]; post-I [−0.75]b |
late-E (pFRG) | Drive RTN [0.24]b,c; early-I (1) [−0.05]; post-I [−0.0275]; pre-I/I [0.013]; late-E [0.024] |
post-I (BötC) | Drive pons [1.45]b; early-I (1) [−0.025] |
post-I (e) (BötC) | Drive pons [0.8]; aug-E [−0.3]; early-I (1) [−0.2] |
pre-I/I (pre-BötC) | Drive RTN [0.22]b; drive pons [0.65]; drive raphe [0.15]; aug-E [−0.01]; post-I [−0.19]; pre-I/I [0.02] |
ramp-I (rVRG) | Drive pons [2]; aug-E [−0.1]; early-I (2) [−0.3]; post-I [−2]; pre-I/I [0.12] |
aug-E, augmenting-expiratory population; BötC, Bötzinger complex; IE, inspiratory-expiratory; pFRG, parafacial respiratory group; post-I, postinspiration; pre-I/I, preinspiratory/inspiratory; RTN, retrotrapezoid nucleus; rostral ventrolateral medulla, RVLM; rVRG, rostral ventral respiratory group.
Not present in Baekey et al. (3);
different from Barnett et al. (7);
must be multiplied by depending on CO2 partial pressure (see methods).