Table 6.
PANTHER and MSigDB pathways showing a significant enrichment of genes associated with survival without BPD at P < 0.05
| Pathway/Gene Set | P Value | FDR | Fold Enrichment | No. of Genes |
|---|---|---|---|---|
| PANTHER | ||||
| Toll receptor signaling pathway | 2.3 × 10−4 | 0.035 | 3.1 | 13 |
| MSigDB | ||||
| Genes within amplicon 1q21 identified in a copy number alterations study of 191 breast tumor samples | 1.5 × 10−15 | 5.1 × 10−12 | 8.6 | 21 |
| Genes with low-CpG-density promoters bearing H3K4me3 marks in embryonic fibroblasts | 4.1 × 10−7 | 6.8 × 10−4 | 2.5 | 35 |
| Nearest neighbors of TAL1, based on the close agreement of their expression profiles with that of TAL1 in pediatric T cell acute lymphoblastic leukemia | 6.7 × 10−6 | 0.0076 | 5.0 | 11 |
| Genes upregulated in lung tissue on LPS aspiration with mechanical ventilation | 2.4 × 10−5 | 0.020 | 2.2 | 32 |
Foreground set of 1,024 genes with association P value <0.05 was compared with a background set of 17,640 genes using Genomic Regions Enrichment of Annotations Tool (GREAT). Gene-based association P values were calculated using versatile gene-based association study (VEGAS). BPD, bronchopulmonary dysplasia; FDR, false discovery rate; MSigDB, Molecular Signature Database; PANTHER, Protein Analysis THrough Evolutionary Relationships.