Table 1.
Alterations of interregional connections between cohorts.
| Correlations |
||||
|---|---|---|---|---|
| Regions | Regions | NC | AD | t-value |
| Decrease in positive correlations | ||||
| ENT_L | INS_R | 0.8 | 0.42 | 4.49 |
| ENT_L | BSTS_R | 0.86 | 0.5 | 4.39 |
| ENT_L | CMF_R | 0.64 | 0.18 | 3.58 |
| TP_L | POPE_R | 0.83 | 0.71 | 3.22 |
| ENT_L | PARC_L | 0.56 | 0.22 | 2.75 |
| ENT_L | POPE_R | 0.86 | 0.67 | 2.54 |
| POPE_R | TP_R | 0.79 | 0.69 | 2.41 |
| ENT_L | POPE_L | 0.79 | 0.45 | 2.37 |
| MT_R | PSTC_R | 0.3 | 0.02 | 2.24 |
| MT_R | SF_R | 0.59 | 0.31 | 2.24 |
| ENT_L | TT_L | 0.71 | 0.4 | 2.15 |
| ENT_L | ENT_R | 0.97 | 0.83 | 2.05 |
| MT_R | PCUN_R | 0.33 | 0.12 | 1.78 |
| MT_R | SP_R | 0.36 | 0.16 | 1.43 |
| MT_R | PREC_R | 0.37 | 0.21 | 1.11 |
| MT_R | RMF_R | 0.24 | 0.12 | 0.86 |
| MT_R | SMAR_R | 0.49 | 0.4 | 0.81 |
| Decrease in negative correlations | ||||
| ENT_L | LOCC_L | -0.97 | -0.8 | -4.65 |
| CUN_L | ENT_L | -0.59 | -0.26 | -4.25 |
| ENT_L | LING_L | -0.89 | -0.62 | -3.71 |
| SF_L | MOF_R | -0.73 | -0.38 | -3.54 |
| POPE_R | SP_R | -0.73 | -0.49 | -3.19 |
| ENT_L | CUN_R | -0.55 | -0.26 | -3.07 |
| ENT_L | LING_R | -0.85 | -0.54 | -2.93 |
| MT_R | RAC_R | -0.32 | -0.04 | -2.68 |
| POPE_R | PREC_R | -0.4 | -0.1 | -2.68 |
| ENT_L | PERI_L | -0.75 | -0.45 | -2.64 |
| POPE_R | PSTC_R | -0.66 | -0.48 | -2.54 |
| ENT_L | LOCC_R | -0.93 | -0.79 | -2.24 |
| ENT_L | PERI_R | -0.75 | -0.51 | -2.15 |
| MT_R | FP_R | -0.44 | -0.25 | -1.90 |
| MT_R | PORB_R | -0.42 | -0.19 | -1.63 |
| MT_R | TP_R | -0.15 | 0.05 | -1.20 |
| MT_R | TT_R | -0.14 | -0.06 | -0.89 |
| Increase in positive correlations | ||||
| ENT_L | FP_L | 0.25 | 0.58 | -4.02 |
| ENT_L | FP_R | 0.3 | 0.59 | -3.50 |
| ENT_L | PORB_L | 0.48 | 0.67 | -3.07 |
| ENT_L | PC_L | 0.29 | 0.61 | -2.93 |
| ENT_L | PORB_R | 0.51 | 0.72 | -2.68 |
| ENT_L | MOF_L | -0.15 | 0.15 | -2.24 |
| MT_R | POPE_R | -0.04 | 0.19 | -2.21 |
| LOF_L | FUSI_R | -0.04 | 0.05 | -0.43 |
| MT_R | INS_R | 0.17 | 0.21 | -0.29 |
| Increase in negative correlations | ||||
| ENT_L | PREC_L | -0.29 | -0.55 | 3.97 |
| ENT_L | SF_L | -0.45 | -0.63 | 3.97 |
| ENT_L | ST_R | 0.06 | -0.29 | 3.54 |
| ENT_L | SF_R | -0.49 | -0.67 | 3.19 |
| ENT_L | ST_L | 0.06 | -0.30 | 3.07 |
| ENT_L | PREC_R | -0.34 | -0.56 | 2.96 |
| ENT_L | SP_L | -0.75 | -0.79 | 2.15 |
| ENT_L | SMAR_R | -0.42 | -0.58 | 2.09 |
| ENT_L | SMAR_L | -0.42 | -0.62 | 2.05 |
The significantly altered connections were listed above in 4 categories (p < 0.05, two-sample one-tailed t-test with FDR correction). The t-test was performed with all the 20 subjects in each group for every connection. The correlations listed above are represented as the average of all the subjects in each group. For each category, the observations are listed in a descendant order of t-value. NC denotes normal control.