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. 2018 Dec 10;9:1779. doi: 10.3389/fphys.2018.01779

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Copyright © 2018 Irion, Parrish, John-Williams, Gultekin and Shehadeh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OPN expression is increased in the cardiomyocytes from the elderly patient with septic shock and coronary artery disease. In the elderly patient with septic shock and >75% occlusion in the left anterior descending (LAD) artery and 100% occlusion in the right circumflex artery (RCA), OPN (white in A) is highly expressed in MLC (green in B), and ACTA1 (red in C) positive cardiomyocytes (arrows). (D) is the merged panel. Scale bar = 50 μm.