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. 2018 Dec 17;11(Suppl 1):i14–i26. doi: 10.1093/ckj/sfy088

FIGURE 3.

FIGURE 3

Prognostic indicators for adult patients with ADPKD and prediction models for disease progression. In adult populations, several indicators for disease progression have been described: age (e.g. age at diagnosis) [44], male sex [45], LBW [46], race [47], BMI [48], BSA [49], PKD genotype [38], other ciliopathy genes [50], high HtTKV [51], low RBF [52], hypertension [44], urologic event [44], chronic asymptomatic pyuria [53], hernia [54], (e)GFR [52], proteinuria [55], cholesterol [49], urinary sodium excretion [49], urine osmolality [49], uric acid [56], thrombocyte count [57], copeptin [58], plasma ADH [59], MCP-1 [60], high protein intake [49], low water intake [61] and smoking [54]. These indicators gave rise to the development of different prediction models [41–43]. ADH, antidiuretic hormone; BMI, body mass index; BSA, body surface area; LBW, low birth weight; MCP-1, monocyte chemoattractant protein 1; PKD1 non-tr, PKD1 non-truncating mutation; PKD1 tr, PKD1 truncating mutation; RBF, renal blood flow.