Table 5.
Fluid challenge-induced changes in hemodynamics.
| Control (n = 25) | SSc (n = 25) | P value | |
|---|---|---|---|
| Δ RA systolic pressure (mmHg) | 2 ± 1 | 3 ± 1 | 0.03 |
| Δ RV systolic pressure (mmHg) | 3 ± 1 | 4 ± 2 | 0.001 |
| Δ Systolic PAP (mmHg) | 3 ± 1 | 4 ± 2 | 0.026 |
| Δ Mean PAP (mmHg) | 3 ± 1 | 5 ± 1 | <0.001 |
| Δ Diastolic PAP (mmHg) | 3 ± 1 | 5 ± 1 | <0.001 |
| Δ PAWP (mmHg) | 3 ± 1 | 5 ± 2 | <0.001 |
| Δ PAWP-RAP (mmHg) | 1 ± 2 | 2 ± 2 | 0.02 |
| Δ Cardiac index (L/min·m2) | 0.6 ± 0.3 | 0.4 ± 0.2 | 0.004 |
| Δ PVR (Wood Units) | −0.4 ± 0.4 | −0.3 ± 0.5 | 0.87 |
| Δ TPG (mmHg) | 0 ± 1 | −1 ± 2 | 0.87 |
| Δ DPG (mmHg) | 0 ± 1 | −1 ± 2 | 0.44 |
Values are expressed as mean ± standard deviation.
P < 0.05 vs. Control.
Δ
: difference between before and after fluid challenge.
DPG, diastolic pressure gradient; PAP, pulmonary artery pressure; PAWP, pulmonary artery wedge pressure; PVR, pulmonary vascular resistance; RAP, right atrial pressure; RV, right ventricular; SSc, systemic sclerosis; TPG, transpulmonary pressure gradient.