Table 3.
Relative changes in hemodynamic and IVUS data after vasodilator challenge in patients with persistent PH after left valve replacement according to the hemodynamic phenotypes.
| Ipc-PH (n = 6) | Cpc-PH (n = 9) | |
|---|---|---|
| ΔmPAo | 14.6 ± 4.8 | 12 ± 4.2 |
| ΔTSVR | –2.9 ± 9.1* | –29.3 ± 8.7 |
| ΔmPAP | 5.8 ± 9.9 | –5.3 ± 6.3 |
| ΔpPAP | –15.9 ± 8.1 | 7.9 ± 11.1 |
| ΔCI | 26.7 ± 9.7* | 77.7 ± 16 |
| ΔSV | 14.4 ± 8.9* | 76.1 ± 21 |
| ΔHR | 7.7 ± 7.4 | 1.3 ± 3.6 |
| ΔTPR | –10 ± 11.7* | –39.7 ± 8.4 |
| ΔPAC | 79 ± 29* | 390 ± 164 |
| ΔEa | –0.02 ± 0.11* | –0.38 ± 0.1 |
| ΔTPR/TSVR | –8.3 ± 5.7 | –15.7 ± 4.1 |
| ΔEM | –4.1 ± 8.6 | 3.8 ± 13 |
Data are presented as mean ± SE of percent variation after vasodilator challenge.
*
P < 0.05 vs. Cpc-PH.
CI, cardiac index; Cpc-PH/Ipc-PH, combined pre and post-capillary/isolated post-capillary pulmonary hypertension; DPG, diastolic pressure gradient; Ea, effective arterial elastance; EM, elastic modulus; HR, heart rate; mPAP/pPAP, mean/pulsatile pulmonary arterial pressure; mPAo, mean aortic pressure; PAC, pulmonary arterial compliance; SV, stroke volume; TPR, total pulmonary resistance; TSVR, total systemic vascular resistance.