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. 2018 Oct 10;293(49):18965–18976. doi: 10.1074/jbc.RA118.004473

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© 2018 Lellahi et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 8. — NEAT1 knockdown amplifies the expression of HSF1 target genes upon heat shock. MCF7 cells were transfected with two different LNA-GapmeR NEAT1 antisense oligos either targeting both isoforms of NEAT1 or solely the long NEAT1_2 isoform and a negative control oligo. After 48 h, cells were subjected to heat shock and recovered for the indicated time periods. The expression of Hsp70, Hsp90, and Hsp27 was determined by RT-qPCR. Knockdown of NEAT1 and NEAT1_2 was verified by RT-qPCR. (***, p ≤ 0.001; **, p ≤ 0.01; *, p ≤ 0.05.)