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. 2018 Oct 17;293(49):19012–19024. doi: 10.1074/jbc.RA118.005365

Figure 7.

Figure 7.

VdesLCCH3 does not assemble in functional heteromultimers with VdesRDL1, VdesRDL3, or VdesRDL4 in X. laevis oocytes. A, GABA concentration-response curves obtained in X. laevis oocytes that express the indicated combinations of GABA receptor subunits. VdesLCCH3 cRNA was injected in 5-fold molar excess compared with VdesRDL1 cRNA. Note that the co-expression of VdesLCCH3 and VdesRDL4 does not lead to functional expression of heteromultimers. B, picrotoxin concentration-response curves obtained in X. laevis oocytes that express VdesRDL3 alone or with VdesLCCH3. C, scatter plot showing fipronil IC50 values in X. laevis oocytes that express the indicated subunit combinations. Bars show means ± S.E. of n = 7–17 oocytes. **, p < 0.01.