Table 1.
Parameters of the concentration-response curves obtained for GABA and fipronil in X. laevis oocytes
ND, not determined. The data are the means ± S.E. of n oocytes.
| RDL1 | RDL1 mut | RDL2 | RDL3 | GRD/LCCH3 | GRD/LCCH3 mut | RDL1/RDL4 | RDL1 mut/RDL4 | RDL1/RDL4 mut | RDL1 mut/RDL4 mut | RDL1/RDL3 | RDL3/RDL4 | RDL1/LCCH3 (1:5) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GABA | |||||||||||||
| EC50 μm | 92 ± 10 | ND | 2.4 ± 0.3 | 37 ± 4 | 35 ± 4 | ND | 102 ± 5 | ND | ND | ND | 107 ± 5 | 39 ± 10 | 131 ± 9 |
| nHill (n) | 2.3 ± 0.1 (11) | 2.5 ± 0.1 (23) | 2.5 ± 0.3 (19) | 1.5 ± 0.3 (9) | 2.3 ± 0.1 (13) | 2.2 ± 0.1 (6) | 2.7 ± 0.2 (14) | 3.0 ± 0.2 (3) | |||||
| Fipronil | |||||||||||||
| IC50 μm (n) | 55 ± 11 (12) | 7.2 ± 1.7a (21) | 3.7 ± 1.3 (8) | 1.1 ± 0.3 (12) | 0.9 ± 0.1 (10) | 2.6 ± 0.4b (17) | 15 ± 2 (15)a | 10.9 ± 3.7c (5) | 57 ± 13 (15) | 6.9 ± 1.2a (22) | 6.0 ± 1.2a (14) | 1.2 ± 0.2 (12) | 44 ± 6 (10) |
a Significantly different from VdesRDL1 (p < 0.01).
b Significantly different from VdesGRD/LCCH3 (p < 0.05).
c Significantly different from VdesRDL1 (p < 0.05).