Figure 5.
Comparison of the CCR5 downmodulation activity of multiplex-synthesized chemokine analogs with those previously obtained for the corresponding reference standard samples. The CCR5 downmodulation activity of each multiplex-synthesized chemokine analog was determined at an Emax concentration (300 nm) in a BRET bystander assay (Fig. S4). According to the results, analogs were stratified into three groups (low, medium and high downmodulation). This figure shows the distribution of downmodulation efficacies determined using molecules produced and tested in the original study (29) for the analogs in each group.