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(a) Luciferase reporter assay with constructs containing HMGA2 3′ UTR. Cells were treated with KCB3602 for 20 h (4 biological replicates, standard deviation, **P < 0.01 from paired two-tailed t test). The expression of the reporter gene (wt) was normalized to that of the control gene (m7). (b) Western blot analysis in JAR cells and PA-1 cells to observe the effect of KCB3602 on the expression of endogenous let-7 target oncogenes. Cells were treated with KCB3602 for 24 h.
