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. 2018 Oct 19;9(12):1205–1210. doi: 10.1021/acsmedchemlett.8b00371

Scheme 2. General Route 2 for Synthesis of Pyrazole Quinolones.

Scheme 2

Conditions and reagents: (a) 2-amino-2-methyl-propanol, ZnCl2, PhCl, 135 °C, 24 h; (b) corresponding benzyl bromide, K2CO3, acetone, reflux, 3 h; (c) Pd2(dba)3, dppp, pyrrolidine, 4 Å M.S., DMF, 110 °C, 6 h; (d) CF3SO3H, n-BuOH, N2, 130 °C, 24 h.