. 2018 Oct 19;9(12):1205–1210. doi: 10.1021/acsmedchemlett.8b00371

Table 2. In Vitro Antimalarial Activities of Selected Quinolones versus W2 and TM90C2B and PfNDH2 Enzyme Inhibition Data^a.

compound	IC₅₀ W2 (nM)	IC₅₀ TM90C2B (nM)	IC₅₀PfNDH2 (nM)
chloroquine	12.3	14.5	ND^b
atovaquone	0.3	9908	10,000
1	26	122	20
4e	33	ND	837
5a	14	ND	ND
5b	11	110	ND
11c	15	500	1,000
11i	49	300	68

50% inhibitory concentration in vitro against P. falciparum chloroquine-resistant W2 strain (Indochina), Atovaquone resistant TM90C2B strain, and PfNDH2 enzyme inhibition data.²⁴

ND, not determined.

Table 2. In Vitro Antimalarial Activities of Selected Quinolones versus W2 and TM90C2B and PfNDH2 Enzyme Inhibition Dataa.

Table 2. In Vitro Antimalarial Activities of Selected Quinolones versus W2 and TM90C2B and PfNDH2 Enzyme Inhibition Data^a.