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. 2018 Oct 19;9(12):1205–1210. doi: 10.1021/acsmedchemlett.8b00371

Table 3. CLogP Value, Melting Point, and Aqueous Solubility at pH 7.4 for Selected 2-Pyrazolyl Quinolones.

compound CLogP melting point (°C) solubilitya (μM)
1 5.67 213 0.03
4e 3.71 194 0.1
5a 4.04 256 0.01
11a 4.24 143 0.2
11c 3.70 172 0.3
11i 3.92 64 0.4
a

Solubility in pH 7.4 PBS buffer.