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. 2018 Nov 16;9(12):1199–1204. doi: 10.1021/acsmedchemlett.8b00364

Table 1. SiteHopper Analysis Comparing the Kinase Binding Site Similarity with CDK9a.

rank kinase max SiteHopper PatchScore
1 CDK9 2.66
2 CDK2 1.86
3 TAOK1 1.81
4 CDC2L5 1.58
5 CDK14 1.58
6 HIPK2 1.48
7 CDKL5 1.47
8 HIPK3 1.42
9 ICK 1.38
10 PFPK5 1.35
11 CDK4-cyclinD1 1.31
a

Only the top 11 hits are shown using the maximum score obtained against all available conformations, see SI.