Figure 2.

Proposed scheme of distribution between active and inactive conformations of MICAL1. The inactive conformation was calculated to prevail approximately 9:1 over the active one in free MICAL.21 (Macro)molecules binding to the C‐terminal domain of MICAL, which includes the Pro‐ and Glu‐rich regions (green) as well as the Rab‐binding domain (RBD, grey) are proposed to stabilize the active conformation. Such molecules would include, e.g., SH3‐containing proteins, Rab proteins or the cytoplasmic side of semaphorin‐activated plexin. The possibility that the active or inactive conformations of MICAL1 are stabilized by dimerization is also included.