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Possible fates of Sec‐selenenic acid in mTrxR. (A) Oxidation of Sec in mTrxR by H2O2 to form Sec‐selenenic acid, followed by resolution by the adjacent Cys residue resulting in the formation of a selenosulfide bond and concomitant enzyme recovery from oxidation. (B) Theoretical inhibition of mTrxR by dimedone via alkylation of Sec‐selenenic acid.
