Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Alkylation of model Sec‐containing peptide with dimedone. Sec was initially protected as Sec(5‐Npys) to prevent oxidation of the selenium atom. Ascorbate selectively removes 5‐Npys protecting group from Sec,17 generating a free Sec‐selenol, which was then oxidized by H2O2 in the presence of dimedone to alkylate the Sec‐selenenic acid.
