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The open LMO active site electrostatically attracts substrate and Loop 4 folding blocks active site access. (A) Molecular surface and electrostatic potential of LMO with Loop 4 removed. FMN in the active site (yellow spheres) is visible through an opening. The surface electrostatic potential (semitransparent) is scaled from red to blue as shown. (B) Same as panel A, but with Loop 4 present.
