Table 1.
Biodistribution of [203Pb]DOTA-PEG4-VMT-MCR1 and [212Pb]DOTA-PEG4-VMT-MCR1 in C57BL/6 mice bearing B16F1 murine melanoma tumors at 1 h and 3 h post tail vein injection. Data presented as percent injected dose per gram of tissue/blood (%ID/g; n = 3 for each time point for each tissue ± SD).
| 1 h |
3 h |
|||
|---|---|---|---|---|
| Tissue | Pb-203 | Pb-212 | Pb-203 | Pb-212 |
| (%ID/g) | (%ID/g) | (%ID/g) | (%ID/g) | |
| Blood | 0.94 ± 0.30 | 1.05 ± 0.17 | 0.40 ± 0.02 | 0.17 ± 0.05 |
| Heart | 0.41 ± 0.13 | 0.62 ± 0.10 | 0.30 ± 0.07 | 0.19 ± 0.04 |
| Liver | 0.88 ± 0.08 | 0.49 ± 0.05 | 0.56 ± 0.03 | 0.35 ± 0.02 |
| Kidneys | 17.18 ± 1.30 | 14.76 ± 1.32 | 9.92 ± 1.44 | 10.65 ± 0.15 |
| Lung | 0.82 ± 0.38 | 1.00 ± 0.03 | 0.54 ± 0.08 | 0.33 ± 0.04 |
| Tumor | 5.20 ± 2.17 | 5.50 ± 0.23 | 5.27 ± 0.73 | 4.08 ± 0.46 |
| Spleen | 0.35 ± 0.18 | 0.52 ± 0.15 | 0.50 ± 0.04 | 0.31 ± 0.02 |
| Muscle | 0.14 ± 0.03 | 0.30 ± 0.03 | 0.18 ± 0.01 | 0.19 ± 0.07 |
| Brain | 0.04 ± 0.00 | 0.09 ± 0.02 | 0.06 ± 0.02 | 0.05 ± 0.01 |