FIG. 4.

Harnessing The Cancer Genome Atlas (TCGA) data for clinical diagnosis. CN-H indicates copy number high (serous or serous-like endometrial carcinoma); CN-L, copy number low (type I EMC); EMC, endometrial carcinoma; MSI-H, microsatellite instability-high; POLE, polymerase E hotspot mutant tumor. EMC*: This may also be applicable to clear cell carcinomas. Most cases can be separated with review of hematoxylin and eosin slides. EMC**: This assay does not distinguish CN-H grade 3 endometrioid carcinoma or CN-H clear cell carcinoma from serous carcinoma.