Table I.
Baseline characteristics of PCOS and control subjects.
| PCOS (n = 750) | Controls (n = 1567) | P-value | |
|---|---|---|---|
| Age (yr) | 27 (23–31.9) | 59.6 (51–68) | <0.0001 |
| BMI (kg/m2) | 31.7 (25.3–37.6) | 30.6 (28.6–33.8) | 0.59 |
| Total Testosterone (nmol/L) | 2.39 (1.77–3.08) | 1.14 (0.88–1.72)a | <0.0001 |
| DHEAS (μmol/L) | 6.05 (4.17–8.53) | 2.72 (1.84–4.48)a | <0.0001 |
| Fasting insulin (pmol/L) | 96.0 (54.6–156.0) | 45.0 (27.0–73.2) | <0.0001 |
| Fasting glucose (mmol/L) | 4.77 (4.50–5.15) | 5.00 (4.66–5.50) | <0.0001 |
| HOMA2-IR | 2.1 (1.4–3.3) | 1.1 (0.77–1.79) | <0.0001 |
| HOMA2-%B | 176.2 (128.9–226.1) | 97.2 (74.9–130.2) | <0.0001 |
Values presented as median (interquartile range). Transformed (log or square root) means were compared using unpaired t-tests. aAndrogen levels were available from 98 deeply phenotyped controls.