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. 2018 Dec 4;34(1):109–117. doi: 10.1093/humrep/dey337

Table II.

Distribution of phthalate, paraben and phenol biomarker concentrations (ng/g creatinine) in prenatal and peripubertal urine samples.

LOD (ng/L) Detection Frequency Geometric mean Percentiles
Biomarker 25th% 50th% 75th% 90th%
Prenatala
 MEP 0.6 99.8% 203.3 85.7 208.6 435.0 866.1
 MBP 0.4 99.2% 24.1 13.4 22.4 42.6 71.0
 MiBP 0.2 94.4% 3.0 1.7 2.8 5.4 8.7
 Triclosan 2.3 73.2% 19.9 <LOD 16.7 112.1 313.4
 Benzophenone-3 0.4 99.5% 23.5 4.5 15.4 136.9 590.9
 Methyl paraben 1 99.9% 136.4 63.9 149.3 345.1 544.2
 Propyl paraben 0.2 96.8% 34.5 9.6 40.8 151.9 403.8
 2,4-dichlorophenol 0.2 100.0% 5.1 2.0 3.5 12.8 38.0
 2,5-dichlorophenol 0.2 100.0% 64.6 14.3 50.6 378.6 763.7
Peripubertalb
 MEP NAc
 MBP NAc
 MiBP NAc
 Triclosan 2.3 68.7% 8.0 <LOD 6.0 22.4 184.1
 Benzophenone-3 0.4 99.7% 17.2 5.8 13.6 36.5 148.0
 Methyl paraben 1 99.7% 44.9 17.1 38.6 115.0 324.2
 Propyl paraben 0.2 97.1% 4.9 1.1 2.8 21.3 107.4
 2,4-dichlorophenol 0.2 94.8% 1.0 0.5 0.9 1.9 3.6
 2,5-dichlorophenol 0.2 95.5% 2.2 0.8 1.6 4.0 17.2

aAverage of concentrations in two maternal urine samples collected in pregnancy.

bOne child urine sample collected at 9 years of age.

cMEP, MBP and MiBP were not measured in child urine samples.

LOD = limit of detection.