Table III.
Adjusteda mean shift (95% confidence intervals) in age at pubertal milestones in girls associated with a 2-fold increase in prenatal and childhood urinary biomarker concentrations.
| Biomarker | Thelarche (B2+) | Pubarche (PH2+) | Menarche |
|---|---|---|---|
| Mean shift (months) | Mean shift (months) | Mean shift (months) | |
| Prenatal concentrationsb (N = 172–177) | |||
| MEP | −1.1 (−2.2, 0.1) | −1.3 (−2.5, −0.1)* | −0.3 (−1.3, 0.6) |
| MBP | −0.5 (−2.4, 1.4) | 0.5 (−1.3, 2.4) | −0.7 (−2.1, 0.7) |
| MiBP | −0.2 (−1.8, 1.5) | −0.3 (−2.0, 1.4) | −0.4 (−1.6, 0.9) |
| Triclosan | −0.1 (−0.8, 0.6) | 0.0 (−0.7, 0.8) | −0.7 (−1.2, −0.2)** |
| Benzophenone-3 | −0.1 (−0.7, 0.6) | 0.3 (−0.4, 1.0) | −0.3 (−0.8, 0.2) |
| Methyl paraben | 0.1 (−1.0, 1.2) | 0.4 (−0.8, 1.6) | −0.7 (−1.6, 0.2) |
| Propyl paraben | 0.1 (−0.6, 0.8) | 0.4 (−0.4, 1.2) | −0.2 (−0.8, 0.4) |
| 2,4-dichlorophenol | −0.9 (−1.9, 0.2) | −0.2 (−1.3, 0.9) | −0.8 (−1.6, 0.0)* |
| 2,5-dichlorophenol | −0.5 (−1.2, 0.3) | −0.1 (−0.9, 0.7) | −0.5 (−1.0, 0.1) |
| Peripubertal concentrationsc (N = 155–157) | |||
| Triclosan | 0.0 (−0.8, 0.8) | 0.7 (−0.1, 1.5) | 0.1 (−0.5, 0.8) |
| Benzophenone-3 | −0.3 (−1.3, 0.7) | −0.5 (−1.4, 0.4) | −0.6 (−1.4, 0.2) |
| Methyl paraben | −1.1 (−2.1, 0.0)* | −1.5 (−2.5, −0.4)** | −0.9 (−1.6, −0.1)* |
| Propyl paraben | −0.5 (−1.2, 0.3) | −0.8 (−1.6, −0.1)* | −0.4 (−1.0, 0.1) |
| 2,4-dichlorophenol | 0.4 (−1.3, 2.0) | 0.6 (−1.0, 2.2) | −0.4 (−1.6, 0.7) |
| 2,5-dichlorophenol | 0.2 (−0.7, 1.1) | 1.0 (0.1, 1.9)* | 0.5 (−0.3, 1.3) |
aAdjusted for maternal education, years in US, maternal pre-pregnancy BMI and family poverty (during pregnancy or at 9 Y, respectively).
bAverage of creatinine-corrected concentrations in two urine samples collected during pregnancy.
cCreatinine-corrected concentrations in one urine sample collected at 9 years of age.
*P < 0.05; **P < 0.01.