Table 1.
The characteristics of MPNs in Malaysia
| No | Characteristics | Total MPNs | JAK2 V617F positivea | JAK2 V617F negativea | p-value |
|---|---|---|---|---|---|
| N (%) | n (%) | n (%) | |||
| 1. | Total patients, n | 1010 | 644 | 222 | |
| 2. | Age at diagnosis, year | ||||
| Mean (sd) | 54.2 (14.88) | 55.9 (13.39) | 49.1 (16.59) | < 0.001 | |
| 95% CI for population mean | 53.32, 55.16 | 54.90, 56.97 | 46.87, 51.26 | ||
| 3. | Sex | ||||
| Female | 488 (48.3) | 317 (49.2) | 99 (44.6) | 0.234 | |
| Male | 522 (51.7) | 327 (50.8) | 123 (55.4) | ||
| 4. | Ethnic groupsb | ||||
| Malay | 447 (44.2) | 310 (48.1) | 84 (37.8) | < 0.001 | |
| Chinese | 412 (40.8) | 253 (39.3) | 104 (46.8) | ||
| Indian | 65 (6.4) | 32 (5.0) | 24 (10.8) | ||
| Native—Sabah | 42 (4.2) | 22 (3.4) | 5 (2.3) | ||
| Native—Sarawak | 19 (1.9) | 13 (2.0) | 0 (0) | ||
| Others | 25 (2.5) | 14 (2.2) | 5 (2.3) | ||
| 5. | MPN sub-types | ||||
| ET | 408 (40.4) | 232 (36.0) | 123 (55.4) | < 0.001 | |
| PV | 385 (38.1) | 300 (46.6) | 49 (22.1) | ||
| PMF | 93 (9.2) | 58 (9.0) | 12 (5.4) | ||
| HES | 31 (3.1) | 0 (0) | 22 (9.9) | ||
| MPN-U | 80 (7.9) | 48 (7.4) | 11 (5.0) | ||
| Others | 5 (0.5) | 1 (0.2) | 2 (0.9) | ||
| Not documented/missing | 8 (0.8) | 5 (0.8) | 3 (1.3) | ||
| 6. | Splenomegaly | ||||
| Yes | 325 (32.2) | 237 (36.8) | 35 (15.8) | < 0.001 | |
| No | 680 (67.3) | 405 (62.9) | 186 (83.8) | ||
| Not documented/missing | 5 (0.5) | 2 (0.3) | 1 (0.4) | ||
| 7. | Presenting vasomotor symptomsc | ||||
| Yes | 218 (21.6) | 154 (23.9) | 36 (16.2) | 0.015 | |
| No | 780 (77.2) | 482 (74.8) | 185 (83.3) | ||
| Not documented/missing | 12 (1.2) | 8 (1.3) | 1 (0.5) | ||
| 8. | Presenting arterial thrombosisd | ||||
| Yes | 209 (20.7) | 149 (23.1) | 28 (12.6) | < 0.001 | |
| No | 792 (78.4) | 492 (76.4) | 193 (86.9) | ||
| Not documented/missing | 9 (0.9) | 3 (0.5) | 1 (0.5) | ||
| 9. | Presenting venous thrombosise | ||||
| Yes | 35 (3.5) | 28 (4.4) | 4 (1.8) | 0.082 | |
| No | 967 (95.7) | 612 (95.0) | 217 (97.7) | ||
| Not documented/missing | 8 (0.8) | 4 (0.6) | 1 (0.5) | ||
| 10. | Presenting bleedingf | ||||
| Yes | 67 (6.6) | 40 (6.2) | 14 (6.3) | 0.956 | |
| No | 936 (92.7) | 602 (93.5) | 207 (93.2) | ||
| Not documented/missing | 7 (0.7) | 2 (0.3) | 1 (0.5) | ||
| 11. | Incidental finding | ||||
| During medical attention for unrelated condition | 494 (48.9) | 324 (50.3) | 109 (49.1) | 0.324 | |
| Health screening | 118 (11.7) | 69 (10.7) | 32 (14.4) | ||
| No | 379 (37.5) | 242 (37.6) | 78 (35.1) | ||
| Not documented/missing | 19 (1.9) | 9 (1.4) | 3 (1.4) | ||
| 12. | BM fibrosis | ||||
| Grade 0 | 157 (15.5) | 94 (14.6) | 38 (17.1) | 0.202 | |
| Grade 1 | 86 (8.5) | 60 (9.3) | 14 (6.3) | ||
| Grade 2 | 48 (4.7) | 33 (5.1) | 12 (5.4) | ||
| Grade 3 | 52 (5.1) | 40 (6.2) | 6 (2.7) | ||
| Grade 4 | 21 (2.1) | 12 (1.9) | 4 (1.8) | ||
| Suboptimal sample | 83 (8.2) | 50 (7.7) | 24 (10.8) | ||
| Not done | 544 (53.9) | 345 (53.6) | 121 (54.5) | ||
| Not documented/missing | 19 (2.0) | 10 (1.5) | 3 (1.4) | ||
aJAK2 V617F mutation result was not reported for 144 patients
bNatives from Sabah and Sarawak, and others are grouped together for Chi square test as the expected count must be at least 2
cPresenting vasomotor symptoms include headache, transient neurologic or ocular symptoms, distal paraesthesias, erythromelalgia, and others
dPresenting arterial thrombosis includes stroke/transient ischemic attack (TIA), acute coronary syndrome, digital gangrene, retinal artery occlusion, mesenteric artery thrombosis, and others
ePresenting venous thrombosis includes hepatic or portal vein thrombosis, deep vein thrombosis (DVT), retinal vein thrombosis, sagittal sinus thrombosis, pulmonary embolism (PE), and others
fPresenting bleedings include gastro intestinal tract (GIT) unspecified, post-surgical bleed, mucocutaneous, and others