Table 1.
Comparisons of ΔMBCI, ΔLNΔI30/ΔG30, ΔP/I and ΔAUCins levels after 8-week treatment between liraglutide and metformin group
| Variable | Liraglutide | Metformin | Difference | P value |
|---|---|---|---|---|
| ΔMBCI | 11.1 (2.81, 43.08) |
0.00 (− 8.16, 10.47) |
6.53 (− 1.75, 14.02) |
0.017 |
| ΔLNΔI30/ΔG30 | 0.44 (0.04, 0.85) |
− 0.09 (− 0.33, 0.36) |
0.21 (− 0.15, 0.68) |
0.049 |
| ΔP/I | − 0.05 (− 0.09, − 0.03) |
− 0.02 (− 0.04, − 0.01) |
− 0.03 (− 0.06, − 0.01) |
0.026 |
| ΔAUCins (mIU/L) | 117 (− 8, 376) |
− 21 (− 341, 109) |
39 (− 33, 227) |
0.013 |
Data are expressed as median (interquartile rang). Deltas (Δ) are presented as the difference of variables before and after treatment
MBCI, modified B cell function index; ΔI30/ΔG30, [(insulin at 30 min) − (insulin at 0 min)]/[(glucose at 30 min) − (glucose at 0 min)]; P/I, proinsuin to insulin ratio; AUCins, insulin area under the curve; LN, log-transformed