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. 2018 Dec 17;24:39. doi: 10.1186/s40409-018-0178-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Crotoxin’s anti-inflammatory modulation. Schematic figure on circulation, tissue and cellular events modulated by Crotoxin and its subunits during inflammatory stimulus. The figure illustrates the migration (adherence, rolling and chemotaxis) and function (phagocytosis and spreading) of blood-derived, resident and tissue necrotic leukocytes, as well as the expression of pro-inflammatory (IL-1β, IL-6, IL-17, TNF-α and INF-γ), anti-inflammatory mediators (IL-10, TGF-β, PGE₂, PGD₂, 15-d-PGJ₂, LXA₄ and arachidonic acid – AA) and surface inflammatory markers (MHC-II, CD40, CD80 and CD86). Green arrows indicate events/mediators that are stimulated/increased by Crotoxin, while red arrows indicate those that are inhibited/reduced. The illustration was created using Mind the Graph platform (www.mindthegraph.com)