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Age ≥65 years
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Autonomous
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Living at home
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Educational level ≥7 years (from the Preparatory Course—1st grade—included)
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Registered to the social security system
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Motivated to effectively participate in the project and signing the informed consent form
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Performance within the normal range on standardized cognitive tests according to agreed study-specific standards (age, sex and education level when available)
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Native French speaker
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Available to attend the intervention for the trial duration (24 months)
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Retired for at least one year
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No strong preference or aversion for an intervention group
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No present or past regular or intensive practice of meditation or comparable practices; the practice is considered as regular and/or intensive if i) it occurs more than one day per week for more than six consecutive months over the last 10 years, and/or in case of more than five consecutive days of intensive practice (internship or retreat) over the past 10 years, and/or of more than 25 days of retreats (cumulatively) within the last 10 years
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Not speaking fluent English
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Safety concerns in relation to MR scanning (claustrophobia, ferromagnetic object) or PET scanning (blood sampling to check hepatic and renal functions are performed before the PET scans; known hypersensibility to Amyvid or Glucotep)
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Presence of a major neurological or psychiatric disorder (including an addiction to alcohol or drugs)
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History of cerebral disease (vascular, degenerative, physical malformation, tumor, or head trauma with loss of consciousness for more than an hour)
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Presence of a chronic disease or acute unstable illness (respiratory, cardiovascular, digestive, renal, metabolic, hematologic, endocrine or infectious)
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Current or recent medication that may interfere with cognitive functioning (psychotropic, antihistaminic with anticholinergic action, anti-Parkinson's, benzodiazepines, steroidal anti-inflammatory long-term treatment, antiepileptic or analgesic drugs), the interfering nature of the different treatments being at the discretion of the investigating doctor
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Being under legal guardianship or incapacitation
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Participation in another biomedical research protocol including the injection of radiopharmaceuticals
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Physical or behavioral inability to perform the follow-up visits as planned in the study protocol
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