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. 2018 Dec 13;12:4231–4240. doi: 10.2147/DDDT.S187177

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© 2018 Zhao et al. This work is published and licensed by Dove Medical Press Limited

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The scheme graph and TEM images of TPGS/LID-NLC, TPGS-NLC, and LID-NLC.

Notes: NLC was prepared by solvent diffusion method. The morphology of NLC was determined by TEM. A drop of NLC suspension was placed on the copper grid and equilibrated for 2 minutes. The liquid was wiped off with a filter paper, and samples were stained with phosphotungstic acid (2%, w/v) for another 2.5 minutes and observed with TEM.

Abbreviations: LID, lidocaine; NLC, nanostructured lipid carriers; TEM, transmission electron microscopy; TPGS, tocopheryl polyethylene glycol 1000 succinate.