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. 2018 Dec 13;12:4231–4240. doi: 10.2147/DDDT.S187177

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© 2018 Zhao et al. This work is published and licensed by Dove Medical Press Limited

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In vitro cumulative LID release from TPGS/LID-NLC and LID-NLC. Data represent the mean±SD, n=3.

Notes: The dialysis bags were immersed in the PBS (pH 7.4) and incubated at 37°C with continuous stirring. Determined amount of samples (0.5 mL) were collected from the dissolution media and analyzed by HPLC.

Abbreviations: HPLC, high-performance liquid chromatography; LID, lidocaine; NLC, nanostructured lipid carriers; TPGS, tocopheryl polyethylene glycol 1000 succinate.