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. 2018 Dec 13;12:4231–4240. doi: 10.2147/DDDT.S187177

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© 2018 Zhao et al. This work is published and licensed by Dove Medical Press Limited

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In vitro drug permeation behaviors of LID from TPGS/LID-NLC, LID-NLC, and free LID accounted by the accumulative penetration amount (Q_n) of LID. Data represent the mean±SD, n=6.

Notes: TPGS/LID-NLC, LID-NLC, Xylocaine Jelly, and free LID were added to the dorsal side of the mice skin. Samples were collected from the receptor compartment and analyzed by HPLC.

Abbreviations: HPLC, high-performance liquid chromatography; LID, lidocaine; NLC, nanostructured lipid carriers; TPGS, tocopheryl polyethylene glycol 1000 succinate.