Figure 6.

In vivo anesthesia effects of TPGS/LID-NLC, LID-NLC, and free LID evaluated by TF latency test. Data represent the mean±SD, n=8.

Notes: TPGS/LID-NLC, LID-NLC, Xylocaine Jelly, free LID, and 0.9% saline solution were applied onto the dorsal surface of the tail. In vivo anesthesia effect could be evaluated using the maximum possible effect calculated by TF latency.

Abbreviations: LID, lidocaine; NLC, nanostructured lipid carriers; TF, tail flick; TPGS, tocopheryl polyethylene glycol 1000 succinate.