Table 2.
In vitro LID permeation parameters of NLC (mean±SD, n=3)
| Formulation | Jss (μg/cm2/hour) | Kp (cm/hour) (×10−3) | Q24 (μg/cm2) | Q48 (μg/cm2) | Q72 (μg/cm2) |
|---|---|---|---|---|---|
| TPGS/LID-NLC | 15.6±1.8 | 10.3±0.9 | 478.2±17.9 | 509.6±21.2 | 547.5±23.6 |
| LID-NLC | 10.6±1.3 | 6.9±0.5 | 308.9±11.7 | 349.3±9.8 | 383.7±13.9 |
| Free LID | 6.8±0.7 | 4.6±0.3 | 211.7±8.5 | 223.4±10.7 | 254.8±9.7 |
| Xylocaine Jelly | 11.8±1.9 | 7.8±0.8 | 362.2±18.1 | 387.3±23.9 | 413.8±27.6 |
Abbreviations: LID, lidocaine; NLC, nanostructured lipid carriers; TPGS, tocopheryl polyethylene glycol 1000 succinate.