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. 2018 Dec 12;11:9013–9025. doi: 10.2147/OTT.S183847

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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CDK1 knockdown inhibits HCT116 and SW480 cell proliferation, promotes apoptosis, and restricts migration and invasion.

Notes: (A) CDK1 protein level in CDK1 siRNA or NC siRNA-transfected HCT116 and SW480 cells was determined using Western blot analysis. *P<0.05. NC siRNA. (B, C) Proliferation and apoptosis of HCT116 and SW480 cells after transfection with CDK1 siRNA or NC siRNA were evaluated using the MTT assay and flow cytometry analysis, respectively. *P<0.05. NC siRNA. (D, E) Cell migration and invasion were detected by migration and invasion assays in HCT116 and SW480 cells after CDK1 siRNA or NC siRNA transfection. *P<0.05. NC siRNA.

Abbreviations: ANTs, adjacent normal tissues; CDK1, cyclin-dependent kinase 1; CRC, colorectal cancer; NCsiRNA, negative control siRNA; RT-qPCR, Reverse transcription-quantitative PCR; siRNA, small interfering RNA.