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. Author manuscript; available in PMC: 2018 Dec 17.
Published in final edited form as: Mol Nutr Food Res. 2018 Apr 14;62(8):e1700770. doi: 10.1002/mnfr.201700770

Figure 2.

Figure 2.

Green tea polyphenyl EGCG is antagonist of GPRC6A. EGCG inhibited GPRC6A ligands, A) T and Arg, B) Ocn-stimulated ERK phosphorylation in HEK-293 cells transfected GPRC6A cDNA. C) GA-stimulated ERK phosphorylation was also blocked by EGCG in HEK-293 cells transfected GPRC6A cDNA. The bar graph in bottom panels depicts fold-increase in ERK activation in response to GA, GE, and OG in HEK-293 transfected with GPRC6A cDNA. Values represent the mean ± SEM. * indicates significant differences from control and stimulated groups at p < 0.05 (n ≥ 4).