Figure 1.

Autophagic flux is closely associated with responses to anti-cancer drugs. (A) Indicated cancer cells were treated without or with erlotinib (20 μM) or osimertinib (5 μM) for 24 h, followed by immunoblot. C-PARP denotes cleaved PARP. (B) Migration and invasion potentials of PC-9 and PC-9/ER cells were determined. ^***p < 0.0005. (C) Cell lysates from the indicated cancer cells were subjected to immunoblot. (D) LC3 puncta expression in PC-9 and PC-9/ER cells was determined by immunofluorescence staining. ^**p < 0.005.