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. Author manuscript; available in PMC: 2019 May 18.
Published in final edited form as: ACS Synth Biol. 2018 May 3;7(5):1179–1187. doi: 10.1021/acssynbio.7b00334

Figure 1.

Figure 1.

Medium-chain fatty acid biosynthesis in Escherichia coli. A. E. coli Type II fatty acid synthase (FAS) extends and reduces an acyl chain bound to acyl-carrier protein (ACP). All enzymes in FAS interact with ACP. Thioesterases (TEs) hydrolyze acyl-ACPs to free fatty acids of different chain lengths according to their substrate specificity. B. Matching the surface interface between the native E. coli AcpP and heterologous medium-chain Acinetobacter baylyi TE, improves medium-chain fatty acid production in E. coli.